Basic Information

Gene symbol CD274 Synonyms B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD274 molecule


Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

GTO ID GTC2012
Trial ID NCT03740256
Disease Stomach Cancer | Salivary Gland Cancer | Head and Neck Squamous Cell Carcinoma | Breast Cancer | Pancreatic Adenocarcinoma | Colorectal Cancer | Esophageal Cancer | Lung Cancer | Bladder Cancer
Altered gene E1A|IL-12A|CD274
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment CAdVEC
Co-treatment HER2 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleA First in Human Phase I Trial of Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR T Cells in Patients With Advanced HER2 Positive Solid Tumors
Year2020
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-43405 VISTA
Vector information
Vectoradenovirus
ConstructAd5-Delta 24
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted geneIL-12; PD-L1
Viral genome modificationCo-infection of oncolytic adenovirus (OAd) with helper-dependent adenovirus (HDAd)
Additional featureHER2-specific autol. CAR T cells

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage CAdVEC: 5E9, HER2 CAR-T cells: 0
Age Adult, Older_Adult
References PMID: 36989357
Cohort2: dose level 2
Administration route intravenous infusion
Dosage CAdVEC: 1E10, HER2 CAR-T cells: 0
Age Adult, Older_Adult
References PMID: 36989357
Cohort3: dose level 3
Administration route intravenous infusion
Dosage CAdVEC: 1E10, HER2 CAR-T cells: 1E6
Age Adult, Older_Adult
References PMID: 36989357
Cohort4: dose level 4
Administration route intravenous infusion
Dosage CAdVEC: 1E11, HER2 CAR-T cells: 1E6
Age Adult, Older_Adult
References PMID: 36989357
Cohort5: dose level 5
Administration route intravenous infusion
Dosage CAdVEC: 1E10, HER2 CAR-T cells: 1E7
Age Adult, Older_Adult
References PMID: 36989357
Cohort6: dose level 6
Administration route intravenous infusion
Dosage CAdVEC: 1E12, HER2 CAR-T cells: 1E7
Age Adult, Older_Adult
References PMID: 36989357
Cohort7: dose level 7
Administration route intravenous infusion
Dosage CAdVEC: 1E12, HER2 CAR-T cells: 1E8
Age Adult, Older_Adult
References PMID: 36989357

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