Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1994
Trial ID NCT03704298
Disease Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Co-treatment Utomilumab
Generation2nd
PhasePhase1
Recruitment statusTerminated
TitleSafety and Efficacy of Axicabtagene Ciloleucel in Combination With Utomilumab in Adults With Refractory Large B-cell Lymphoma
Year2018
CountryUnited States
Company sponsorKite, A Gilead Company
Other ID(s)KTE-C19-111
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 15
Age Adult, Older_Adult
Lymph depletion Yes

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