Basic Information

Gene symbol CD7 Synonyms GP40, LEU-9, TP41, Tp40 Type of gene protein-coding
Description CD7 molecule

GTO ID GTC1983
Trial ID NCT03690011
Disease B-Cell Acute Lymphoblastic Leukemia | T-Cell Non-Hodgkin's Lymphoma
Altered gene CD7
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD7 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleCell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells
Year2018
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-43761 - CRIMSON NE
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E7 cells/m^2, 3E7 cells/m^2, 1E8 cells/m^2
Donor type Autologous
Pts 21
Age Child, Adult, Older_Adult
Lymph depletion Yes

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