Basic Information

Gene symbol PRAME Synonyms CT130, MAPE, OIP-4, OIP4 Type of gene protein-coding
Description PRAME nuclear receptor transcriptional regulator

GTO ID GTC1981
Trial ID NCT03686124
Disease Solid Tumor
Altered gene PRAME
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment IMA203;IMA203CD8
HLAHLA phenotype positive
PhasePhase1
Recruitment statusRecruiting
TitlePhase 1 Study Evaluating Genetically Modified Autologous T Cells Expressing a TCR Recognizing a Cancer/Germline Antigen as Monotherapy or in Combination With Nivolumab in Patients With Recurrent and/or Refractory Solid Tumors
Year2018
CountryUnited States|Germany
Company sponsorImmatics US, Inc.
Other ID(s)IMA203-101

Clinical Result

Cohort1: IMA203/IMA203CD8
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: IMA203/IMA203CD8_Nivolumab
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes

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