Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1980
Trial ID NCT03685786
Disease B-Cell Acute Lymphocytic Leukemia | B-Cell Lymphoma | B-Cell Chronic Lymphocytic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleCART19 Cells Treatment of MRD of B Cell Malignancies and Then Auto-HSCT
Year2018
CountryChina
Company sponsorShenzhen Second People's Hospital
Other ID(s)Weihong Chen06062018
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage total 0.5~4E8 cells, 0.5~4E7 cells on day 0, 1.5E7~1.2E8 cells on day 1, 3E7~2.4E8 cells on day 2
Donor type Autologous
Pts 20
Age Child, Adult, Older_Adult

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