Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1977
Trial ID NCT03676504
Disease Follicular Lymphoma | Mantle Cell Lymphoma | Childhood Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation3rd
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleTreatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR
Year2018
CountryGermany
Company sponsorUniversity Hospital Heidelberg
Other ID(s)HD-CAR-1
Vector information
Vectorretrovirus
ConstructscFv-CD28-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/m^2, 5E6 cells/m^2, 20E6 cells/m^2, 5E7 cells/m^2, 10E7 cells/m^2, 20E7 cells/m^2
Donor type Autologous
Pts 68
Age Child, Adult, Older_Adult
Lymph depletion Yes

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