Basic Information

Gene symbol MET Synonyms AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description MET proto-oncogene, receptor tyrosine kinase

Gene symbol CD274 Synonyms B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD274 molecule

GTO ID GTC1972
Trial ID NCT03672305
Disease Hepatocellular Carcinoma
Altered gene c-MET|PD-L1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment c-Met/PD-L1 CAR-T cells
PhaseEarly_Phase1
Recruitment statusUnknown
TitleClinical Study on the Efficacy and Safety of c-Met/PD-L1 CAR-T Cell Injection in the Treatment of HCC
Year2018
CountryChina
Company sponsorThe Second Hospital of Nanjing Medical University
Other ID(s)JGZNO1
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous drip
Dosage 2E6 cells/kg
Pts 50
Age Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph