Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1969
Trial ID NCT03666000
Disease B-Cell Acute Lymphoblastic Leukemia | Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment PBCAR0191
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleDose-escalation, Dose-expansion Study of Safety of PBCAR0191 in Patients With r/r NHL and r/r B-cell ALL
Year2018
CountryUnited States
Company sponsorPrecision BioSciences, Inc.
Other ID(s)PBCAR0191-01

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 3E5 cells/kg, 1E6 cells/kg, 3E6 cells/kg, 6E6 cells/kg, 500E6 cells
Donor type Allogeneic
Pts 120
Age Adult, Older_Adult
Lymph depletion Yes

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