Basic Information

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC1967
Trial ID NCT03664635
Disease B-Cell Lymphoma | Non-Hodgkin's Lymphoma
Altered gene CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MB-CAR-T20.1
Generation2nd
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleMB-CART20.1 Lymphoma
Year2018
CountryGermany
Company sponsorMiltenyi Biomedicine GmbH
Other ID(s)M-2016-312
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage 1E5 cell/kg
Donor type Autologous
Pts 6
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route None
Dosage 1E6 cell/kg
Donor type Autologous
Pts 9
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route None
Dosage 3E6 cell/kg
Donor type Autologous
Pts 9
Age Adult, Older_Adult

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