Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC1945
Trial ID NCT03620058
Disease Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-T22-65s|CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleCART22 Alone or in Combination With huCART19 for ALL
Year2018
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)IRB # 830049; UPCC #12418
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort1: CD22
Administration route None
Donor type Autologous
Pts 23
Age Adult, Older_Adult
Cohort2: CD22+CD19
Administration route None
Donor type Autologous
Age Adult, Older_Adult

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