Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol EGFR Synonyms ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description epidermal growth factor receptor

GTO ID GTC1943
Trial ID NCT03618381
Disease Sarcoma | Germ Cell Tumor
Altered gene EGFR|CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EGFR806 CAR-T cells|CD19 CAR-T cell
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleEGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults
Year2018
CountryUnited States
Company sponsorSeattle Children's Hospital
Other ID(s)STRIvE-01
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort1: EGFR
Administration route None
Donor type Autologous
Age Child, Adult
Cohort2: EGFR+CD19
Administration route None
Donor type Autologous
Pts 36
Age Child, Adult

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