Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC1938
Trial ID NCT03605238
Disease Neuromyelitis Optica
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusWithdrawn
TitleTreatment of Relapsed and/or Refractory AQP4-IgG Seropositive NMOSD by Tandem CAR T Cells Targeting CD19 and CD20
Year2018
CountryChina
Company sponsorChinese PLA General Hospital
Other ID(s)CHN-PLAGH-NO-S2018-002-02
Vector information
Vectorretrovirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1~2E5 cells/kg, 3~6E5 cells/kg, 1~2E6 cells/kg
Donor type Autologous
Pts 0
Age Child, Adult, Older_Adult

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