Basic Information

Gene symbol CCR4 Synonyms CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description C-C motif chemokine receptor 4

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

GTO ID GTC1934
Trial ID NCT03602157
Disease Gray Zone Lymphoma | Sezary's Disease | Mycosis Fungoides | Lymphoma | Lymphomatoid Papulosis | Cutaneous Lymphoma
Altered gene CD30|CCR4
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ATLCAR.CD30.CCR4
Co-treatment Bendamustine
PhasePhase1
Recruitment statusRecruiting
TitleStudy of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL
Year2018
CountryUnited States
Company sponsorUNC Lineberger Comprehensive Cancer Center
Other ID(s)LCCC 1606-ATL

Clinical Result

Cohort1: dose level 1_ATLCAR.CD30.CCR4 cells
Administration route intravenous infusion
Dosage 2E7 cells/m^2
Pts 59
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: dose level 1_ATLCAR.CD30.CCR4 cells_ATLCAR.CD30 cells
Administration route intravenous infusion
Dosage 2E7 cells/m^2, 1E8 cells/m^2
Pts 59
Age Adult, Older_Adult
Lymph depletion Yes
Cohort3: dose level 2_ATLCAR.CD30.CCR4 cells
Administration route intravenous infusion
Dosage 5E7 cells/m^2
Pts 59
Age Adult, Older_Adult
Lymph depletion Yes
Cohort4: dose level 2_ATLCAR.CD30.CCR4 cells_ATLCAR.CD30 cells
Administration route intravenous infusion
Dosage 5E7 cells/m^2, 1E8 cells/m^2
Pts 59
Age Adult, Older_Adult
Lymph depletion Yes
Cohort5: dose level 3_ATLCAR.CD30.CCR4 cells
Administration route intravenous infusion
Dosage 1E8 cells/m^2
Pts 59
Age Adult, Older_Adult
Lymph depletion Yes
Cohort6: dose level 3_ATLCAR.CD30.CCR4 cells_ATLCAR.CD30 cells
Administration route intravenous infusion
Dosage 1E8 cells/m^2, 1E8 cells/m^2
Pts 59
Age Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph