Basic Information

Gene symbol tk

GTO ID GTC1929
Trial ID NCT03596086
Disease Brain Glioblastoma Multiforme | Astrocytoma
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment Adv-HSV-tk
PhasePhase1|Phase2
Recruitment statusRecruiting
TitlePhase I-II Study Evaluating HSV-tk + Valacyclovir Gene Therapy Combination With Radiotherapy and Chemotherapy for Recurrent Glioblastoma Multiforme
Year2018
CountryUnited States
Company sponsorThe Methodist Hospital Research Institute
Other ID(s)Pro00016414
Vector information
Vectoradenovirus
ConstructADV/HSV-tk
Vector typeadenoviral vector
Transgene/Inserted geneherpes simplex virus (HSV) thymidine kinase gene

Clinical Result

Cohort 1
Administration route intratumoral injection
Age Adult, Older_Adult

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