Basic Information

Gene symbol E6 Synonyms None Type of gene protein-coding
Description protein E6*;transforming protein E6

GTO ID GTC1916
Trial ID NCT03578406
Disease Head and Neck Squamous Cell Carcinoma | Cervical Cancer
Altered gene E6
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment HPV-16 E6 TCR-T cells
PhasePhase1
Recruitment statusUnknown
TitleTwo-Arm Open-Labeled Trial of HPV-E6-Specific TCR-T Cells With or Without Anti-PD1 Auto-secreted Element in the Treatment of HPV-Positive Head and Neck Carcinoma or Cervical Cancer
Year2018
CountryChina
Company sponsorXinqiao Hospital of Chongqing
Other ID(s)XQDC20180520

Clinical Result

Cohort1: HPV E6 TCR-T cell
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion No
Cohort2: HPV E6 TCR-T cell_anti-PD1 auto-secreted element
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion No

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