Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1905
Trial ID NCT03559439
Disease B-Cell Lymphoma | B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleCD19-targeting CAR T Cells in Relapsed or Refractory CD19 Positive B-cell Malignancies
Year2018
CountryChina
Company sponsorShanghai Tong Ren Hospital
Other ID(s)PTA001
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5 cells/kg, 2E6 cells/kg, 6E6 cells/kg
Donor type Autologous
Pts 9
Age Adult, Older_Adult

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