Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC1902
Trial ID NCT03548207
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Carvykti|Ciltacabtagene Autoleucel|Cilta-cel|JNJ-68284528
Location approved US, EU, UK, Japan, Australia, Canada
Generation2nd
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-Cell Maturation Antigen (BCMA) in Participants With Relapsed or Refractory Multiple Myeloma
Year2018
CountryJapan
Company sponsorJanssen Research & Development, LLC
Other ID(s)CR108480|2018-000121-32|68284528MMY2001
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneBCMA-binding single domain; CD3ζ T-cell activation domain; 4-1BB costimulatory domain

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 106
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 65/97(CR)
Adverse reactions 38/106(All-cause mortality); 54/106(Blood and lymphatic system disorders; Cardiac disorders; Eye disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Nervous system disorders; Psychiatric disorders; Renal and urinary disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)
References PMID: 34175021

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