Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1900
Trial ID NCT03544723
Disease Head and Neck Squamous Cell Carcinoma
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-p53
PhasePhase2
Recruitment statusUnknown
TitleA Phase 2, Multi-Center, Open Label Study to Evaluate Adenoviral p53 (Ad-p53) in Combination With Immune Checkpoint Inhibitor Therapy in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Tumors Approved for Anti-PD-1 or Anti-PD-L1 Therapy
Year2018
CountryUnited States
Company sponsorMultiVir, Inc.
Other ID(s)Ad-p53-002
Vector information
Vectoradenovirus
ConstructAdV-p53
Vector typeadenoviral vector
Transgene/Inserted genehuman p53 gene

Clinical Result

Cohort 1
Administration route intratumoral injection
Age Adult, Older_Adult
References PMID: 34676147

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