Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1895
Trial ID NCT03528421
Disease Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment IM19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleAssessment of Safety and Efficacy of IM19 for Relapsed or Refractory NHL Patients
Year2018
CountryChina
Company sponsorBeijing Immunochina Medical Science & Technology Co., Ltd.
Other ID(s)YMCART201705
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ
Transgene/Inserted geneFMC63-derived CD19-specific scFv; CD28 co-stimulatory molecule; intracellular signaling domain of CD3ζ
Regulatory elementEF1α promoter

Clinical Result

Cohort 1
Administration route None
Dosage 0.75~5E5 cells/kg
Pts 30
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 31650026

Relationship Graph

Overview of Knowledge Graph