Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

GTO ID GTC1891
Trial ID NCT03517631
Disease HIV Infection
Altered gene CCR5
Therapeutic/Target gene Target gene
TherapyshRNA
Treatment shRNA-modified CD34+ cells
PhasePhase1
Recruitment statusUnknown
TitleA Pilot Study to Evaluate Efficacy and Safety of Multiplexed shRNA-modified CD34+ Cells in HIV-infected Patients.
Year2018
CountryChina
Company sponsorShanghai Public Health Clinical Center
Other ID(s)KL1702
Vector information
Vectorlentivirus
Transgene/Inserted genemultiplexed shRNAs in the same vector that target CCR5 and HIV genome

Clinical Result

Cohort1: No busulfan preconditioning
Administration route None
Age Adult
Cohort2: Low dose busulfan preconditioning
Administration route None
Dosage busulfan, 1 mg/kg, single dose, every 6 hours for 4 times
Age Adult
Cohort3: High dose busulfan preconditioning
Administration route None
Dosage busulfan, 1 mg/kg, single dose, every 6 hours for 8 times
Age Adult

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