Basic Information

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B

Gene symbol FOLH1 Synonyms FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, PSMA, mGCP Type of gene protein-coding
Description folate hydrolase 1

Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC1880
Trial ID NCT03491683
Disease Glioblastoma
Altered gene WT1|PSMA|TERT|IL-12A|IL-12B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment INO-5401|INO-9012
Co-treatment Cemiplimab|Radiation Therapy|Temozolomide
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleAn Open-Label, Multi-Center Trial of INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With REGN2810 in Subjects With Newly-Diagnosed Glioblastoma (GBM)
Year2018
CountryUnited States
Company sponsorInovio Pharmaceuticals
Other ID(s)GBM-001
Vector information
Vectorplasmid

Clinical Result

Cohort 1
Administration route intramuscular injection
Dosage 3 mg/plasmid every three weeks for four doses, 1 mg/plasmid every three weeks for four doses
Age Adult, Older_Adult

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