Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1877
Trial ID NCT03483103
Disease Non-Hodgkin's Lymphoma | B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Breyanzi|Lisocabtagene maraleucel|liso-cel|JCAR017
Location approved US, Japan, EU, Switzerland, UK, Canada
Generation2nd
PhasePhase2
Recruitment statusCompleted
TitleLisocabtagene Maraleucel (JCAR017) as Second-Line Therapy (TRANSCEND-PILOT-017006)
Year2018
CountryUnited States
Company sponsorJuno Therapeutics, a Subsidiary of Celgene
Other ID(s)17006
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti‐CD19 single‐chain variable fragment; 4‐1BB costimulatory motif; CD3ζ T‐cell activation domain

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 100E6 cells, single infusion
Donor type Autologous
Pts 74
Age Adult, Older_Adult

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