Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC1867
Trial ID NCT03448978
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusCompleted
TitleAutologous CD8+ T-cells Expressing an Anti-BCMA CAR in Patients With Myeloma
Year2018
CountryUnited States
Company sponsorCartesian Therapeutics
Other ID(s)241-59-88
Vector information
Vectorother
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 2.4E9 cells, three times over 2 week
Donor type Autologous
Pts 38
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 32632095

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