Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1863
Trial ID NCT03436771
Disease Multiple Myeloma | Mantle Cell Lymphoma | Non-Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia | Follicular Lymphoma | Diffuse Large B-Cell Lymphoma
Altered gene CD19|BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Breyanzi|Lisocabtagene maraleucel|liso-cel|JCAR017;JCARH125|Orvacabtagene Autoleucel
Location approved US, Japan, EU, Switzerland, UK, Canada
Generation2nd
Recruitment statusTerminated
TitleLong-term Follow-up Study for Patients Previously Treated With a Juno CAR T-Cell Product
Year2018
CountryUnited States
Company sponsorJuno Therapeutics, a Subsidiary of Celgene
Other ID(s)LTFU001
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti‐CD19 single‐chain variable fragment; 4‐1BB costimulatory motif; CD3ζ T‐cell activation domain

Clinical Result

Cohort1: CD19
Administration route intravenous infusion
Pts 4
Age Child, Adult, Older_Adult
Cohort2: BCMA
Administration route intravenous infusion
Pts 4
Age Child, Adult, Older_Adult

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