Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC1832
Trial ID NCT03370887
Disease Heart Failure
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapymRNA
Treatment AZD8601
PhasePhase2
Recruitment statusCompleted
TitleA Randomized, Double-blind, Placebo-controlled, Multi-centre, Sequential Design, Phase IIa Study to Evaluate Safety and Tolerability of Epicardial Injections of AZD8601 During Coronary Artery Bypass Grafting Surgery
Year2018
CountryFinland|Germany|Netherlands
Company sponsorAstraZeneca
Other ID(s)D9150C00003

Clinical Result

Cohort1: AZD8601_dose level 1
Administration route epicardial injection
Dosage AZD8601, 0, 5 mg/mL, 30 injections of 0.1 mg (3 mg per patient)
Pts 3
Age Adult, Older_Adult
References PMID: 36528793
Cohort2: AZD8601_dose level 2
Administration route epicardial injection
Dosage AZD8601, 5 mg/mL, 30 injections of 0.1 mg (30 mg per patient)
Pts 0
Age Adult, Older_Adult
References PMID: 36528793
Cohort3: AZD8601_dose level 3
Administration route epicardial injection
Dosage Placebo, 30 injections per patient on a single occasion
Pts 7
Age Adult, Older_Adult
References PMID: 36528793

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