Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC1826
Trial ID NCT03361748
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment Abecma|bb2121|BMS-986395|Idecabtagene vicleucel|ide-cel
Location approved US, Canada, EU, UK, Japan, Israel, Switzerland
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleEfficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma
Year2017
CountryBelgium|Canada|France|Germany|Italy|Japan|Spain|United States
Company sponsorCelgene
Other ID(s)BB2121-MM-001|U1111-1202-5554|2017-002245-29
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route None
Dosage 15~450E6 cells
Donor type Autologous
Pts 140
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 42/128(CR); 52/128(PR). The median progression-free survival was 8.8 months (95% confidence interval, 5.6 to 11.6).
Adverse reactions 117/128(neutropenia); 89/128(anemia); 81/128(thrombocytopenia); 107/128(CRS); 23/128(neurotoxic effects)
References DOI: 10.1056/NEJMoa2024850

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