Basic Information

Gene symbol ADCY6 Synonyms AC6, LCCS8 Type of gene protein-coding
Description adenylate cyclase 6

GTO ID GTC1825
Trial ID NCT03360448
Disease Heart Failure
Altered gene ADCY6
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment RT-100
PhasePhase3
Recruitment statusWithdrawn
TitleRandomized, Phase 3, Placebo-Controlled Double-Blind, Multicenter Trial of a One Time Intracoronary Administration of Ad5.HAC6 Gene Transfer for Patients With Reduced Left Ventricular Heart Failure
Year2017
CountryUnited States
Company sponsorRenova Therapeutics
Other ID(s)RT-01-HF-REF
Vector information
Vectoradenovirus
ConstructAd5.hAC6
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted genehuman adenylyl cyclase type 6 gene
Regulatory elementa cytomegalovirus (CMV) promoter
Viral genome modificationThe E1 and partial E3 regions of the parental adenovirus DNA are deleted.

Clinical Result

Cohort 1
Administration route intracoronary injection
Age Adult, Older_Adult
References PMID: 29763816

Relationship Graph

Overview of Knowledge Graph