Basic Information

Gene symbol KIT Synonyms C-Kit, CD117, MASTC, PBT, SCFR Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description KIT proto-oncogene, receptor tyrosine kinase

Gene symbol PROM1 Synonyms AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description prominin 1


Gene symbol MUC1 Synonyms ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description mucin 1, cell surface associated

GTO ID GTC1822
Trial ID NCT03356782
Disease Sarcoma | Osteosarcoma | Ewing Sarcoma
Altered gene CD133|GD2|MUC1|CD117
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD133/GD2/Muc1/CD117 CAR-T cells
Generation4th
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleSafety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas
Year2017
CountryChina
Company sponsorShenzhen Geno-Immune Medical Institute
Other ID(s)GIMI-IRB-17016

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E6~E7 cells/kg
Pts 20
Age Child, Adult, Older_Adult

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