Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CLDN18 Synonyms SFTA5, SFTPJ Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description claudin 18

Gene symbol GPC3 Synonyms DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 Type of gene protein-coding
Description glypican 3

GTO ID GTC1795
Trial ID NCT03302403
Disease B-Cell Leukemia | B-Cell Lymphoma | Pancreatic Carcinoma | Hepatocellular Carcinoma | Multiple Myeloma | Adenocarcinoma of Esophagogastric Junction
Altered gene CD19|BCMA|GPC3|CLDN18
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA/CD19/CLDN18/GPC3 CAR-T cells
Recruitment statusActive, Not Recruiting
TitleClinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors
Year2017
CountryChina
Company sponsorFirst Affiliated Hospital of Wenzhou Medical University
Other ID(s)CGZ001
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 18
Age Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph