Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol TNFRSF13B Synonyms CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description TNF receptor superfamily member 13B

GTO ID GTC1786
Trial ID NCT03287804
Disease Multiple Myeloma
Altered gene BCMA|TACI
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment APRIL CAR-T cells
PhasePhase1|Phase2
Recruitment statusTerminated
TitleAPRIL CAR T Cells (AUTO2) Targeting BCMA and TACI for the Treatment of Multiple Myeloma
Year2017
CountryUnited Kingdom
Company sponsorAutolus Limited
Other ID(s)AUTO2-MM1|2016-003893-42

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 15E6 cells, 350E6 cells
Donor type Autologous
Pts 12
Age Adult, Older_Adult
Lymph depletion Yes

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