Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC1764
Trial ID NCT03241940
Disease Recurrent Adult Acute Lymphocytic Leukemia | Acute Lymphoblastic Leukemia | Childhood B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitlePhase I Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies
Year2017
CountryUnited States
Company sponsorStanford University
Other ID(s)IRB-41383|NCI-2017-01415|PEDSCCT5007|IRB-41383

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 3E5 cells/kg (±20%), 1E6 cells/kg (±20%), 3E6 cells/kg (±20%), 1E7 cells/kg (±20%)
Donor type Autologous
Pts 50
Age Child, Adult
Lymph depletion Yes
References PMID: 34889384 | 32929049

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