Basic Information



Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC1746
Trial ID NCT03190824
Disease Melanoma
Altered gene E1A|E1B|TERT
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Telomelysin|OBP-301
PhasePhase2
Recruitment statusUnknown
TitleOpen-label, Multi-center Phase IIa Study to Evaluate the Efficacy, Safety, and Immunological Response of OBP-301, Telomerase Specific Replication-competent Oncolytic Adenovirus in Patients With Unresectable Metastatic Melanoma
Year2017
CountryUnited States
Company sponsorSyneos Health
Other ID(s)TL03001|Interventional
Vector information
Vectoradenovirus
ConstructAd5-hTERT-E1A-IRES-E1B
Vector typeattenuated type 5 adenovirus (Ad5) vector
Transgene/Inserted genehTERT, which can be utilized as a molecular switch for the selective expression of target genes in tumor cells.
Regulatory elementa human telomerase reverse transcriptase gene (hTERT) promoter

Clinical Result

Cohort 1
Administration route injection
Dosage 1E12 vp/mL
Pts 4
Age Adult, Older_Adult

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