Basic Information

Gene symbol EGFR Synonyms ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description epidermal growth factor receptor

GTO ID GTC1741
Trial ID NCT03182816
Disease Advanced Solid Tumor
Altered gene EGFR
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EGFR CAR-T cells
PhasePhase1|Phase2
Recruitment statusUnknown
TitleCTLA-4 and PD-1 Antibodies Expressing EGFR-CAR-T Cells for EGFR Positive Advanced Solid Tumor
Year2017
CountryChina
Company sponsorShanghai Cell Therapy Research Institute
Other ID(s)H2017-03-P01
Vector information
VectorpiggyBac transposon system
Additional featureanti-CTLA-4/PD-1

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2~5E7 cells/kg
Donor type Autologous
Pts 40
Age Adult, Older_Adult

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