Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1737
Trial ID NCT03173417
Disease Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment IM19 CAR-T cells
PhasePhase1|Phase2
Recruitment statusCompleted
TitleSafety and Efficacy Evaluation of IM19 CAR-T Cells (IM19CAR-T)
Year2017
CountryChina
Company sponsorBeijing Immunochina Medical Science & Technology Co., Ltd.
Other ID(s)YMCART201702

Clinical Result

Cohort 1
Administration route None
Pts 115
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 102/110(CR). One-year leukemia-free survival (LFS) was 58%, and 1-year overall survival (OS) was 64% for the 110 patients.
Adverse reactions Most patients had only mild cytokine release syndrome and neurotoxicity.
References PMID: 32453841

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