Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1728
Trial ID NCT03153462
Disease Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Primary Mediastinal B-Cell Lymphoma | B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment YesCAR-Ta|Axicabtagene Ciloleucel|axi-cel
Generation2nd
Recruitment statusApproved For Marketing
TitleAxicabtagene Ciloleucel Expanded Access Study
Year2017
CountryUnited States
Company sponsorKite, A Gilead Company
Other ID(s)KTE-C19-109|2015-005007-86
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 61
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 29/61(CR); 9/61(PR)
Adverse reactions 13%(CRS); 28%(NEs)
References DOI: 10.1182/blood-2020-136136

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