Basic Information

Gene symbol MAGEA4 Synonyms CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B Type of gene protein-coding
Description MAGE family member A4

GTO ID GTC1723
Trial ID NCT03132922
Disease Esophagus Squamous Cell Carcinoma | Ovarian Cancer | Stomach Cancer | Lung Non-Small Cell Carcinoma | Myxoid Liposarcoma | Urethra Cancer | Head and Neck Cancer | Synovial Sarcoma | Melanoma
Altered gene MAGE-A4
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-A4 TCR-T cells
HLAHLA-A*02
PhasePhase1
Recruitment statusActive, Not Recruiting
TitlePhase 1 Dose Escalation, Multi-tumor Study to Assess the Safety, Tolerability and Antitumor Activity of Genetically Engineered MAGE-A4c1032 T in HLA-A2+ Subjects With MAGE-A4 Positive Tumors
Year2017
CountryUnited States
Company sponsorAdaptimmune
Other ID(s)ADP-0044-001
Vector information
Vectorlentivirus
Transgene/Inserted genethe gene of affinity-enhanced MAGE-A4-specific T-cell receptor

Clinical Result

Cohort1: esophageal SSC
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 2/35(death due to aplastic anemia/ischemic cerebrovascular); 21/35(CRS); 1/35(ICANS); 1/35(encephalopathy); 6/35(tremor/headache); 9/35(skin rash)
References PMID: 36624315
Cohort2: ovarian cancer
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 8
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort3: Gastric Cancer
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort4: Non-small Cell Lung Cancer
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort5: myxiod/round cell liposarcoma
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort6: urothelial cancer
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort7: Head and Neck Cancer
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort8: synovial sarcoma
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 16
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315
Cohort9: melanoma
Administration route infusion
Dosage 0.1~9.98E9 cells
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 36624315

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