Basic Information

Gene symbol IL3RA Synonyms CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra Type of gene protein-coding
Description interleukin 3 receptor subunit alpha

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

Gene symbol CD38 Synonyms ADPRC 1, ADPRC1, cADPR1 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description CD38 molecule

Gene symbol CD70 Synonyms CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A Type of gene protein-coding
Description CD70 molecule

GTO ID GTC1720
Trial ID NCT03125577
Disease B-Cell Malignancy
Altered gene CD19|CD20|CD22|CD30|CD38|CD70|CD123
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-T cells
Generation4th
PhasePhase1|Phase2
Recruitment statusUnknown
TitleCombination CAR-T Cell Therapy Targeting Hematological Malignancies
Year2017
CountryChina
Company sponsorShenzhen Geno-Immune Medical Institute
Other ID(s)GIMI-IRB-17005
Vector information
Vectorlentivirus
ConstructscFv-CD28-4-1BB-CD3ζ|scFv-CD28-CD27-CD3ζ|scFv-CD28-ICOS-CD3ζ|scFv-CD28-OX40-CD3ζ|scFv-CD28-IL-15Ra-CD3ζ
Additional featureiCasp9

Clinical Result

Cohort 1
Administration route infusion
Pts 100
Age Child, Adult, Older_Adult
Lymph depletion Yes
References PMID: 30444200

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