Basic Information

Gene symbol HA Synonyms None Type of gene protein-coding
Description haemagglutinin

GTO ID GTC1717
Trial ID NCT03121339
Disease Seasonal Influenza
Altered gene HA
Therapeutic/Target gene Therapeutic gene
TherapydsRNA
Treatment VXA-A1.1|Ad-HA-dsRNA
PhasePhase1
Recruitment statusCompleted
TitleA Phase 1, Open-Label, Randomized, 2×2 Crossover Study of Pharmacodynamics Comparing the Impact of Tablet Size and Fasting Status With an Oral Human Influenza A/California/04/2009 (H1N1) HA Adenoviral-Vector Based Vaccine and dsRNA Adjuvant
Year2017
CountryUnited States
Company sponsorVaxart
Other ID(s)VXA02-RLT-01
Vector information
Vectoradenovirus
ConstructAd-HA-dsRNA
Vector typeadenoviral vector
Transgene/Inserted genehaemagglutinin (A/CA/04/2009) transgene
Regulatory elementa cytomegalovirus promoter; a molecular dsRNA hairpin driven by a separate promoter

Clinical Result

Cohort1: Fasting Condition
Administration route oral
Dosage VXA-A1.1 H1 Tablet Vaccine (small), 140 mg; VXA-A1.1 H1 Tablet Vaccine (small), 275 mg
Age Adult
References PMID: 31978351
Cohort2: Fed Condition
Administration route oral
Dosage VXA-A1.1 H1 Tablet Vaccine (small), 140 mg; VXA-A1.1 H1 Tablet Vaccine (small), 275 mg
Age Adult
References PMID: 31978351

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