Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC1710
Trial ID NCT03098355
Disease B-Cell Leukemia | B-Cell Lymphoma
Altered gene CD19|CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD22 CAR-T cells
Generation4th
PhasePhase1|Phase2
Recruitment statusSuspended
TitleInterleukin-2 Following 4SCAR19/22 T Cells Targeting Refractory and/or Recurrent B Cell Malignancies
Year2017
CountryChina
Company sponsorZhujiang Hospital
Other ID(s)anti-CD19/22 cells
Vector information
Vectorlentivirus
ConstructscFv-CD28-4-1BB-CD3ζ
Additional featureiCasp9, IL-2

Clinical Result

Cohort 1
Administration route None
Dosage 0.5~5E6 cells/kg
Donor type Autologous
Pts 30
Age Child
Lymph depletion Yes

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