Basic Information

Gene symbol FOLH1 Synonyms FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, PSMA, mGCP Type of gene protein-coding
Description folate hydrolase 1

GTO ID GTC1709
Trial ID NCT03089203
Disease Prostate Cancer
Altered gene PSMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-T-PSMA-TGFβRDN
PhasePhase1
Recruitment statusRecruiting
TitleCART-PSMA-TGFβRDN Cells for Castrate-Resistant Prostate Cancer
Year2017
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 32816, 826250
Vector information
Vectorlentivirus
Additional featureTGFβRDN

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1~3E7 cells/m^2, 1~3E8 cells/m^2, 1~3E7 cells/m^2, 0.70~10E8 cells/m^2
Donor type Autologous
Pts 19
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 35314843

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