Basic Information

Gene symbol CD5 Synonyms LEU1, T1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description CD5 molecule

GTO ID GTC1703
Trial ID NCT03081910
Disease Non-Hodgkin's Lymphoma | T Cell Lymphoblastic Lymphoma | T-Cell Acute Lymphoblastic Leukemia
Altered gene CD5
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD5 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleAutologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen
Year2017
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-40466, MAGENTA
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort1: Autologous cells
Administration route intravenous infusion
Dosage 1E7 cells/m^2, 5E7 cells/m^2, 1E8 cells/m^2
Donor type Autologous|Allogeneic
Pts 42
Age Child, Adult, Older_Adult
Lymph depletion Yes
References PMID: 34274536
Cohort2: Allogeneic cells
Administration route intravenous infusion
Dosage 1E7 cells/m^2, 5E7 cells/m^2, 1E8 cells/m^2
Donor type Autologous|Allogeneic
Age Child, Adult, Older_Adult
Lymph depletion Yes
References PMID: 34274536

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