Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1702
Trial ID NCT03076437
Disease Chronic Lymphocytic Leukemia | Acute Lymphoblastic Leukemia | Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhasePhase1|Phase2
Recruitment statusCompleted
TitleAnti-CD19 Chimeric Antigen Receptor (CAR)-Transduced T Cell Therapy for Patients With B Cell Malignancies
Year2016
CountryChina
Company sponsorShenzhen Institute for Innovation and Translational Medicine
Other ID(s)SIITM20160115
Vector information
Vectorlentivirus|retrovirus
ConstructscFv-4-1BB-CD3ζ|scFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 28
Age Child, Adult, Older_Adult
Lymph depletion Yes

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