Basic Information

Gene symbol PMEL Synonyms D12S53E, HMB-45, HMB45, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100 Type of gene protein-coding
Description premelanosome protein

GTO ID GTC1701
Trial ID NCT03070392
Disease Uveal Melanoma
Altered gene gp100
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment gp100 TCR-T cells
HLAHLA-A*02:01
PhasePhase2
Recruitment statusActive, Not Recruiting
TitleA Phase II Randomized, Open-label, Multi-center Study of the Safety and Efficacy of IMCgp100 Compared With Investigator Choice in HLA-A*0201 Positive Patients With Previously Untreated Advanced Uveal Melanoma
Year2017
CountryUnited States
Company sponsorImmunocore Ltd
Other ID(s)IMCgp100-202

Clinical Result

Cohort 1
Administration route None
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 34551229

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