Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol EGFR Synonyms ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description epidermal growth factor receptor

GTO ID GTC1700
Trial ID NCT03070327
Disease Multiple Myeloma
Altered gene EGFR|BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EGFRt/BCMA-41BBz CAR-T cells
Co-treatment Lenalidomide
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleBCMA Targeted CAR T Cells With or Without Lenalidomide for the Treatment of Multiple Myeloma
Year2017
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)17-025

Clinical Result

Cohort 1
Administration route None
Dosage 1E6 cells/kg, 3E6 cells/kg, 1E7 cells/kg, 3E5 cells/kg
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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