Basic Information

Gene symbol MET Synonyms AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description MET proto-oncogene, receptor tyrosine kinase

GTO ID GTC1697
Trial ID NCT03060356
Disease Malignant Adenoma | Breast Cancer
Altered gene c-MET
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment cMet CAR-T cells
Generation2nd
PhaseEarly_Phase1
Recruitment statusTerminated
TitleAutologous T Cells Expressing MET scFv CAR (RNA CART-cMET)
Year2016
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 11916, 825376
Vector information
Vectorelectroporation
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E8 cells
Donor type Autologous
Pts 77
Age Adult, Older_Adult

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