Basic Information

Gene symbol CD80 Synonyms B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description CD80 molecule

Gene symbol CD86 Synonyms B7-2, B7.2, B70, CD28LG2, LAB72 Type of gene protein-coding
Description CD86 molecule

Gene symbol CD274 Synonyms B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD274 molecule

GTO ID GTC1696
Trial ID NCT03060343
Disease Lung Non-Small Cell Carcinoma
Altered gene PD-L1|CD80|CD86
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment PD-L1/CD80/CD86 CAR-T cells
PhaseEarly_Phase1
Recruitment statusUnknown
TitleZeushield Cytotoxic T Lymphocytes (Z-CTLs) for Relapsed or Refractory Non Small Cell Lung Cancer (NSCLC)
Year2017
CountryChina
Company sponsorYu Fenglei
Other ID(s)Z-NSCLC-01

Clinical Result

Cohort 1
Administration route None
Dosage 1E5 cells/kg, 1E6 cells/kg, 1E7 cells/kg
Donor type Autologous
Pts 10
Age Adult, Older_Adult

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