Basic Information


GTO ID GTC1695
Trial ID NCT03054298
Disease Peritoneal Mesothelioma | Fallopian Tube Cancer | Ovarian Cancer | Peritoneal Carcinoma | Mesotheliomas Pleural | Lung Adenocarcinoma
Altered gene MESO
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MESO CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleCAR T Cells in Mesothelin Expressing Cancers
Year2017
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)826085 (UPCC 02916)
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion|intrapleural infusion
Dosage 1~3E7 cells/m^2
Donor type Autologous
Pts 27
Age Adult, Older_Adult
Lymph depletion Yes/No

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