Basic Information

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

GTO ID GTC1693
Trial ID NCT03049449
Disease Diffuse Large B-Cell Lymphoma | Nasal Type Extranodal NK/T-Cell Lymphoma | Peripheral T-Cell Lymphoma | Anaplastic Large Cell Lymphoma
Altered gene CD30
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD30 CAR-T cells
PhasePhase1
Recruitment statusCompleted
TitleT Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas
Year2017
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)170048|17-C-0048

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.3~18E6 cells/kg
Donor type Autologous
Pts 26
Age Adult, Older_Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph