Basic Information

Gene symbol PDCD1 Synonyms CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description programmed cell death 1

GTO ID GTC1691
Trial ID NCT03044743
Disease Gastric Carcinoma | Nasopharyngeal Carcinoma | T-Cell Lymphoma | Adult Hodgkin's Lymphoma | Diffuse Large B-Cell Lymphoma
Altered gene PDCD1
Therapeutic/Target gene Target gene
TherapyGene editing
Treatment PD-1 Knockout T cells
PhasePhase1|Phase2
Recruitment statusUnknown
TitleA Phase I/II Trial of PD-1 Knockout EBV-CTLs for Advanced Stage EBV Associated Malignancies
Year2017
CountryChina
Company sponsorYang Yang
Other ID(s)PD-1-KO-EBV-CTL

Clinical Result

Cohort 1
Administration route infusion
Dosage 2E7 cells/kg. Each cycle is divided into three administrations, with 20%, 30% and 50% respectively.
Donor type autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes
References DOI: 10.1200/JCO.2018.36.15_suppl.TPS3118

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