Basic Information

Gene symbol EPCAM Synonyms Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, LYNCH8, M4S1, MIC18, MK-1, MOC-31, TACSTD1, TROP1 Type of gene protein-coding
Description epithelial cell adhesion molecule

GTO ID GTC1682
Trial ID NCT03013712
Disease Esophageal Carcinoma | Colon Cancer | Pancreatic Cancer | Prostate Cancer | Stomach Cancer | Liver Cancer
Altered gene EpCAM
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EpCAM CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusUnknown
TitleA Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer
Year2017
CountryChina
Company sponsorFirst Affiliated Hospital of Chengdu Medical College
Other ID(s)CARTEPC-001
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route vascular interventional mediated or endoscopy
Dosage 1~10E6 cells/kg
Donor type Autologous
Pts 60
Age Adult, Older_Adult

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